Police are urging Prof Wyndham Lathem, 42, and Andrew Warren, 56, to "do the right thing and turn yourself in".
Arrests warrants were issued after Trenton Cornell-Duranleau, 25, was found dead in Prof Lathem's flat in Chicago on 27 July.
"The victim had several lacerations to the body," the police said.
Wyndham Lathem is a microbiology professor at Northwestern University in Illinois, who specialises in the bacteria that caused the bubonic plague.
Andrew Warren is a senior treasury assistant at Oxford's Somerville College.
The police warned that the suspects were believed to be "armed and dangerous", and were possibly driving a Hyundai sedan.
Mr Cornell-Duranleau, originally from Michigan, worked as a cosmetologist in Chicago.
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